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- Title
Cervical nitric oxide metabolite levels and clinical variables as predictive factors of high-grade cervical intraepithelial neoplasia.
- Authors
Giannella, Luca; Prandi, Sonia; Giulini, Simone; Mfuta, Kabala; Torrini, Barbara; Boselli, Fausto
- Abstract
Purpose: To create a prediction model of high-grade cervical intraepithelial neoplasia (CIN) based on clinical variables and the cervical nitric oxide metabolite (NOx) levels of study participants. Methods: This comparative study included 694 women undergoing colposcopy due to abnormal pap smear results. On the basis of the cervical biopsy results, the women were divided into the ≤CIN 1 or CIN 2-3 group. The two groups were compared in terms of cervical NOx levels and clinical variables. Univariate, multivariate, and receiver-operating characteristic curve analysis were performed. Results: Multivariate analysis showed that CIN 2-3 associated with more than two cervical biopsies [odds ratio (OR) = 5.16], high-grade squamous intraepithelial lesion cytology (OR = 16.19), condom non-use (OR = 4.28), cervical NOx levels ≤99.9 μmol/L (OR = 16.62), more than four lifetime male sexual partners (OR = 10.56), and age at first coitus of ≤15 years old (OR = 3.54). This combined model had a sensitivity of 86.49 %, a specificity of 90.74 %, a positive predictive value of 64.0 %, and a negative predictive value of 97.2 %. Conclusions: In the present sample, high-grade CIN associated with decreased cervical NOx levels. Thus, along with some clinical variables, cervical NOx levels may be an additional marker of cervical dysplasia.
- Subjects
COMPARATIVE studies; CERVICAL intraepithelial neoplasia; PHYSIOLOGICAL effects of nitric oxide; METABOLITE analysis; PREDICTION models; PAP test; COLPOSCOPY
- Publication
Archives of Gynecology & Obstetrics, 2013, Vol 288, Issue 5, p1095
- ISSN
0932-0067
- Publication type
Article
- DOI
10.1007/s00404-013-2850-8