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- Title
Extended-Spectrum Beta-Lactamase-Producing Bacteria in a Urology Ward: Epidemiology, Risk Factors and Antimicrobial Susceptibility Patterns.
- Authors
Medina-Polo, José; Arrébola-Pajares, Ana; Pérez-Cadavid, Santiago; Benítez-Sala, Raúl; Sopeña-Sutil, Raquel; Lara-Isla, Alba; Alsonso-Isa, Manuel; Gil-Moradillo, Javier; Justo-Quintas, Juan; Miranda-Utrera, Natalia; Aguilar-Gisbert, Luis; Passas-Martínez, Juan Bautista; Tejido-Sánchez, Ángel
- Abstract
Introduction: Our aim was to describe the incidence and risk factors associated with extended-spectrum beta-lactamase (ESBL)-producing Enterobacteriaceae and their resistance rate in a urological ward. Material and Methods: We carried out a prospective observational study from November 2011 to December 2014, reviewing healthcare-associated infections (HAIs) in our department. We evaluated the infections caused by ESBL-producing Enterobacteriaceae. Results: The incidence of HAIs in our urology ward was 6.8%. Enterobacteriaceae including Escherichia coli (24.9%), Klebsiella spp. (12.1%), Enterobacter spp. (5.9%), Morganella spp. (1.5%), Proteus spp. (1.5%), and Citrobacter spp. (1.5%) represented 47.4% of the isolated pathogens. The percentage of ESBL-producing Enterobacteriaceae was 26.4. Risk factors associated with a higher incidence of ESBL-producing bacteria were prior urinary tract infection (UTI; p < 0.001), hypertension (p = 0.042), immunosuppression (p = 0.004), and urinary stone (p = 0.027). The multivariable analysis confirmed prior UTI, immunosuppression and urinary stone as risk factors. ESBL-producing strains showed resistance rates of 85.3% for fluoroquinolones and 11.8% for carbapenems. Moreover, 16.7% of ESBL-Klebsiella were resistant to carbapenems. Conclusions: ESBL-producing enterobacteria are associated with higher cross resistance to antibiotics such as quinolones. Higher resistance rates are reported in ESBL-producing Klebsiella. Among patients admitted in a urology ward, risk factors for ESBL-producing strains were previous UTI, immunosuppression, and urinary stone. © 2015 S. Karger AG, Basel
- Subjects
BETA lactamases; UROLOGY; EPIDEMIOLOGY; MICROBIAL sensitivity tests; ENTEROBACTERIACEAE; IMMUNOSUPPRESSION; HOSPITAL wards
- Publication
Urologia Internationalis, 2015, Vol 95, Issue 3, p288
- ISSN
0042-1138
- Publication type
Article
- DOI
10.1159/000439441