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- Title
A dynamic model for in-vitro evaluation of antimicrobial action by simulation of the pharmacokinetic profiles of antibiotics.
- Authors
Navashin, S. M.; Fomina, I. P.; Firsov, A. A.; Chernykh, V. M.; Kuznetsova, S.; Kuznetsova, S M
- Abstract
The general principles of in-vitro simulation of drug pharmacokinetic profiles for linear one-, two- and multi-compartment models are described. An in-vitro dynamic model constructed on the basis of these, incorporating a novel filtration unit to provide efficient filtration of drugs at constant inoculum size, was used to study the antimicrobial action of sisomicin on Escherichia coli A 20363, in conditions simulating the pharmacokinetic profile observed in humans after a single intramuscular dose of 1 mg/kg.
- Publication
Journal of Antimicrobial Chemotherapy (JAC), 1989, Vol 23, Issue 3, p389
- ISSN
0305-7453
- Publication type
journal article