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- Title
Pharmacokinetics of cefotetan in patients with end-stage renal failure on maintenance dialysis.
- Authors
Browning, M J; Holt, H A; White, L O; Chapman, S T; Banks, R A; Reeves, D S; Yates, R A
- Abstract
The pharmacokinetics of a single intravenous dose of cefotetan were studied in 17 volunteer patients with end-stage renal failure, requiring intermittent haemodialysis in 12 cases or undergoing continuous ambulatory peritoneal dialysis in 5 cases. Between haemodialysis the mean plasma elimination half life was 20.4 h (S.E.M. +/- 2.1). This decreased to 7.5 h (S.E.M. +/- 0.6) during haemodialysis. In patients treated by continuous ambulatory peritoneal dialysis the mean plasma elimination half life was 15.5 h (S.E.M. +/- 1.9). Small amounts of cefotetan (5-9% of the administered dose) were recovered in the peritoneal dialysates removed over the 24 h following the dose.
- Subjects
CEFOTETAN; CEPHALOSPORINS; CHRONIC kidney failure; COMPARATIVE studies; CONTINUOUS ambulatory peritoneal dialysis; DYNAMICS; HEMODIALYSIS; RESEARCH methodology; MEDICAL cooperation; RESEARCH; TIME; EVALUATION research
- Publication
Journal of Antimicrobial Chemotherapy (JAC), 1986, Vol 17, Issue 6, p103
- ISSN
0305-7453
- Publication type
journal article