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- Title
Harnessing the biology of IL-7 for therapeutic application.
- Authors
Mackall, Crystal L.; Fry, Terry J.; Gress, Ronald E.
- Abstract
Interleukin-7 (IL-7) is required for T cell development and for maintaining and restoring homeostasis of mature T cells. IL-7 is a limiting resource under normal conditions, but it accumulates during lymphopaenia, leading to increased T cell proliferation. The administration of recombinant human IL-7 to normal or lymphopenic mice, non-human primates and humans results in widespread T cell proliferation, increased T cell numbers, modulation of peripheral T cell subsets and increased T cell receptor repertoire diversity. These effects raise the prospect that IL-7 could mediate therapeutic benefits in several clinical settings. This Review summarizes the biology of IL-7 and the results of its clinical use that are available so far to provide a perspective on the opportunities for clinical application of this cytokine.
- Subjects
INTERLEUKINS; T cells; DENDRITIC cells; LYMPHOBLASTIC leukemia; SEVERE combined immunodeficiency
- Publication
Nature Reviews Immunology, 2011, Vol 11, Issue 5, p330
- ISSN
1474-1733
- Publication type
journal article
- DOI
10.1038/nri2970