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- Title
黄芪多糖在正畸骨改建中的作用.
- Authors
王慧达; 孙小桐; 毕 蓝; 王子轩
- Abstract
BACKGROUND: Astragalus membranaceus is a commonly used traditional Chinese herb. Astragalus polysaccharide is the central active ingredient extracted from the stem or root of Astragalus membranaceus. It has the functions of anti-tumor, improving memory, anti-osteoporosis, regulating blood glucose and regulating immunity. Studies have shown that astragalus polysaccharides can regulate the movement speed of orthodontic teeth by affecting periodontal tissue remodeling and inhibit root resorption and postoperative recurrence caused by orthodontic treatment. Local western medicine combined with astragalus injection can significantly promote ulcer healing and delay ulcer recurrence in patients with oral ulcer. OBJECTIVE: To review the effects of astragalus polysaccharides on tooth movement, root resorption, recurrence after orthodontic surgery and the treatment of oral ulcer combined with western drug therapy during orthodontic treatment, thereby providing reference for its better application in orthodontic treatment. METHODS: The first author searched WanFang, CNKI, and PubMed for relevant literature about the effect of astragalus polysaccharides on orthodontic tooth movement, periodontal tissue remodeling, root resorption, orthodontic oral ulcer and postoperative recurrence published in the past 15 years. The keywords were “Astragalus membranaceus, orthodontic tooth movement, periodontium remodeling, osteoblast, osteoclast, orthodontically induced inflammatory root resorption, recurrence after orthodontic treatment, orthodontic mouth ulcers” in Chinese and English. Finally, 54 eligible articles were included for review. RESULTS AND CONCLUSION: Astragalus polysaccharide plays an important role in the adjustment of tissue remodeling as well as in orthodontic treatment, including accelerating tooth movement, promoting periodontal tissue remodeling, inhibiting root resorption and postoperative recurrence. Local western drug therapy combined with astragalus injection can also treat oral ulcer and reduce its occurrence by improving the imbalance of T cell subsets. However, most of them are limited to the animal experimental stage and more clinical studies are needed. Astragalus polysaccharide, as a commonly used ingredient of Chinese herbal medicine, is expected to be used as an adjunct to orthodontic treatment in the future to enhance and maintain therapeutic effects. The combination of Traditional Chinese Medicine and tissue engineering can provide further strategies to promote the development of regenerative medicine.
- Subjects
ROOT resorption (Teeth); ASTRAGALUS membranaceus; CORRECTIVE orthodontics; BONE resorption; ASTRAGALUS (Plants); CHINESE medicine; TISSUE remodeling; PLATELET-rich plasma
- Publication
Chinese Journal of Tissue Engineering Research / Zhongguo Zuzhi Gongcheng Yanjiu, 2023, Vol 27, Issue 32, p5214
- ISSN
2095-4344
- Publication type
Article
- DOI
10.12307/2023.817