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- Title
Biomechanical Leg Muscle Function During Stair Ambulation in Men Receiving Androgen Deprivation Therapy.
- Authors
Cheung, Ada S; Gray, Hans A; Schache, Anthony G; Hoermann, Rudolf; Bicknell, Jarrod; Joon, Daryl Lim; Zajac, Jeffrey D; Pandy, Marcus G; Grossmann, Mathis
- Abstract
<bold>Background: </bold>The role of testosterone in maintaining functional performance in older men remains uncertain.<bold>Methods: </bold>We conducted a 12-month prospective, observational case-control study including 34 men newly commencing androgen deprivation therapy for prostate cancer and 29 age-matched prostate cancer controls. Video-based motion capture and ground reaction force data combined with computational musculoskeletal modeling, and data were analyzed with a linear mixed model.<bold>Results: </bold>Compared with controls over 12 months, men receiving androgen deprivation therapy had a mean reduction in circulating testosterone from 14.1 nmol/L to 0.4 nmol/L, associated with reductions in peak knee extension torque, mean adjusted difference (MAD) -0.07 Nm/kg (95% confidence interval [CI]: -0.18, 0.04), p = .009, with a corresponding more marked decrease in quadriceps force MAD -0.11 × body weight (BW) [-0.27, 0.06], p = .045 (equating to a 9 kg force reduction for the mean body weight of 85 kg), and decreased maximal contribution of quadriceps to upward propulsion, MAD -0.47 m/s2 [-0.95, 0.02], p = .009. We observed between-group differences in several other parameters, including increased gluteus maximus force in men receiving androgen deprivation therapy, MAD 0.11 × BW [0.02, 0.20], p = .043, which may be compensatory.<bold>Conclusions: </bold>Severe testosterone deprivation over 12 months is associated with selective deficits in lower-limb function evident with an important task of daily living.
- Subjects
ANDROGENS; LEG muscles; MOTION capture (Human mechanics); OLDER men; STAIRS; BODY weight; CASTRATION-resistant prostate cancer; LEG physiology; SKELETAL muscle physiology; ANTIANDROGENS; SKELETAL muscle; TESTOSTERONE; CASE-control method; ACTIVITIES of daily living; PROSTATE tumors; LONGITUDINAL method; KINEMATICS
- Publication
Journals of Gerontology Series A: Biological Sciences & Medical Sciences, 2020, Vol 75, Issue 9, p1715
- ISSN
1079-5006
- Publication type
journal article
- DOI
10.1093/gerona/glz169