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- Title
A Case for Promoting Movement Medicine: Preventing Disability in the LIFE Randomized Controlled Trial.
- Authors
Fanning, Jason; Rejeski, W Jack; Chen, Shyh-Huei; Nicklas, Barbara J; Walkup, Michael P; Axtell, Robert S; Fielding, Roger A; Glynn, Nancy W; King, Abby C; Manini, Todd M; McDermott, Mary M; Newman, Anne B; Pahor, Marco; Tudor-Locke, Catrine; Miller, Michael E; Investigators, LIFE Study; LIFE Study Investigators
- Abstract
<bold>Background: </bold>The movement profile of older adults with compromised function is unknown, as is the relationship between these profiles and the development of major mobility disability (MMD)-a critical clinical outcome. We first describe the dimensions of movement in older adults with compromised function and then examine whether these dimensions predict the onset of MMD.<bold>Methods: </bold>Older adults at risk for MMD (N = 1,022, mean age = 78.7 years) were randomized to receive a structured physical activity intervention or health education control. We assessed MMD in 6-month intervals (average follow-up of 2.2 years until incident MMD), with activity assessed at baseline, 6-, 12- and 24-month follow-up via accelerometry.<bold>Results: </bold>A principal components analysis of 11 accelerometer-derived metrics yielded three components representing lifestyle movement (LM), extended bouts of moderate-to-vigorous physical activity (MVPA), and stationary body posture. LM accounted for the greatest proportion of variance in movement (53%). Within health education, both baseline LM (HR = 0.74; 95% CI 0.62 to 0.88) and moderate-to-vigorous physical activity (HR = 0.69; 95% CI 0.54 to 0.87) were associated with MMD, whereas only LM was associated with MMD within physical activity (HR = 0.74; 95% CI 0.61 to 0.89). There were similar nonlinear relationships present for LM in both physical activity and health education (p < .04), whereby risk for MMD was lower among individuals with higher levels of LM.<bold>Conclusions: </bold>Both LM and moderate-to-vigorous physical activity should be central in treatment regimens for older adults at risk for MMD.<bold>Trial Registration: </bold>clinicaltrials.gov Identifier NCT01072500.
- Subjects
PHYSICAL activity; PRINCIPAL components analysis; OLDER people; POSTURE; PEDOMETERS; HEALTH education; PHYSICAL activity measurement
- Publication
Journals of Gerontology Series A: Biological Sciences & Medical Sciences, 2019, Vol 74, Issue 11, p1821
- ISSN
1079-5006
- Publication type
journal article
- DOI
10.1093/gerona/glz050