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- Title
Strategies and Challenges in Clinical Trials Targeting Human Aging.
- Authors
Newman, John C.; Milman, Sofiya; Hashmi, Shahrukh K.; Austad, Steve N.; Kirkland, James L.; Halter, Jeffrey B.; Barzilai, Nir
- Abstract
Interventions that target fundamental aging processes have the potential to transform human health and health care. A variety of candidate drugs have emerged from basic and translational research that may target aging processes. Some of these drugs are already in clinical use for other purposes, such as metformin and rapamycin. However, designing clinical trials to test interventions that target the aging process poses a unique set of challenges. This paper summarizes the outcomes of an international meeting co-ordinated by the NIH-funded Geroscience Network to further the goal of developing a translational pipeline to move candidate compounds through clinical trials and ultimately into use. We review the evidence that some drugs already in clinical use may target fundamental aging processes. We discuss the design principles of clinical trials to test such interventions in humans, including study populations, interventions, and outcomes. As examples, we offer several scenarios for potential clinical trials centered on the concepts of health span (delayed multimorbidity and functional decline) and resilience (response to or recovery from an acute health stress). Finally, we describe how this discussion helped inform the design of the proposed Targeting Aging with Metformin study.
- Subjects
PHYSIOLOGICAL aspects of aging; GERONTOLOGY; METFORMIN; TRANSLATIONAL research; RAPAMYCIN; ACARBOSE; AGING; ANTIBIOTICS; BIOLOGICAL models; CLINICAL trials; CONFERENCES &; conventions; CLINICAL drug trials; EXPERIMENTAL design; GLYCOSIDASES; HYPOGLYCEMIC agents; MEDICAL research; CHEMICAL inhibitors; PHARMACODYNAMICS
- Publication
Journals of Gerontology Series A: Biological Sciences & Medical Sciences, 2016, Vol 71, Issue 11, p1424
- ISSN
1079-5006
- Publication type
journal article
- DOI
10.1093/gerona/glw149