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- Title
内皮克隆形成细胞的研究进展和应用前景.
- Authors
贾静; 师二姣; 郭利丽; 冯玲; 王少帅
- Abstract
Endothelial colony-forming cells(ECFCs), a subtype of endothelial progenitor cells(EPCs), play an important role in maintaining vascular homeostasis. ECFCs are characterized by robust proliferative potential, colony forming ability and ability to form intrinsic in vivo vessels upon transplantation into immunodeficient mice. They have been successfully isolated from the peripheral blood(PB-ECFCs), umbilical cord blood(CB-ECFCs), bone marrow and wall of numerous arterial and venous vessels, and derived from human-induced pluripotent stem cells(hiPSCs). Here we will briefly describe the involvement of ECFCs in various diseases, summarize the current progress and application prospect of CB-ECFCs in ischemia repair, tissue engineering and tumor therapy, and highlight the limitations of in vivo studies in mice and the improvement of cell culture conditions in vitro.
- Publication
Progress in Modern Biomedicine, 2019, Vol 19, Issue 8, p1583
- ISSN
1673-6273
- Publication type
Article
- DOI
10.13241/j.cnki.pmb.2019.08.041