We found a match
Your institution may have rights to this item. Sign in to continue.
- Title
Postoperative Intensity-Modulated Radiotherapy Improved Survival in Lymph Node-Positive or Stage III Thoracic Esophageal Squamous Cell Carcinoma.
- Authors
Zhang, Wencheng; Liu, Xiao; Xiao, Zefen; Zhang, Hongxing; Chen, Dongfu; Feng, Qinfu; Zhou, Zongmei; Lv, Jima; Liang, Jun; Hui, Zhouguang; Wang, Lvhua; Yin, Weibo; Cheng, Guiyu; Sun, Kelin; Liu, Xiangyang; Fang, Dekang; He, Jie
- Abstract
Background: The aim of this study was to retrospectively analyze the effect of postoperative intensity-modulated radiotherapy (IMRT) on recurrence and survival in lymph node-positive or stage III thoracic esophageal squamous cell carcinoma (TESCC) patients, and evaluate its role in TESCC therapy. Methods: We enrolled 538 patients who underwent radical resection with (S + R) or without (S) postoperative IMRT. The median total postoperative IMRT dose was 60 Gy. The Kaplan-Meier method, log-rank test, and chi-square test were used for survival rate calculation, univariate analysis, and sites of failure analysis, respectively. Results: The 5-year overall survival (OS) and disease-free survival rates were 32.7 and 27.3%, respectively. The 5-year OS rates of lymph node-positive S and S + R patients were 28.4 and 38.8%, respectively (p < 0.001). The 5-year OS rates of stage III S and S + R patients were 24.0 and 38.0%, respectively (p = 0.001). Postoperative IMRT resulted in significantly decreased intrathoracic and supraclavicular recurrence, and obviously delayed median local recurrence and systemic metastases. Systemic metastases increased following postoperative IMRT. Conclusion: Postoperative IMRT reduces local recurrence and improves survival in lymph node-positive or stage III TESCC patients, providing a rationale for selection criteria for postoperative IMRT in TESCC. © 2015 S. Karger GmbH, Freiburg
- Publication
Oncology Research & Treatment, 2015, Vol 38, Issue 3, p97
- ISSN
2296-5270
- Publication type
Article
- DOI
10.1159/000375391