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- Title
Measurement of the placental total antioxidant status in preeclamptic women using a novel automated method.
- Authors
Ozturk, Ebru; Balat, Ozcan; Acılmıs, Yurdanur Gurcay; Ozcan, Caglayan; Pence, Sadrettin; Erel, Özcan
- Abstract
We aimed to measure the levels of total antioxidant status (TAS) in placental samples from preeclamptic pregnant women and evaluate the relation of placental TAS, total oxidant status (TOS) and oxidative stress index (OSI) with fetomaternal compartments using the more recently designated Erel method. Thirty four preeclamptic and 27 normotensive pregnant women were enrolled in this prospective controlled study. Subjects were selected from women attending the Obstetrics and Gynecology Department of Gaziantep University. TAS, TOS, OSI were measured from placental, maternal and cord blood samples using a novel automated method. Statistical analyses were performed with SPSS for Windows version 13.0 (SPSS Inc., Chicago, IL, USA). The TAS level of the placenta was evaluated as significantly lower ( P < 0.001) in preeclamptic women compared to normotensive women. In preeclamptic pregnancies, while the placental TAS level was not correlated with placental TOS level, the TAS levels of maternal plasma ( P < 0.001; r = 0.584) and cord plasma ( P < 0.005; r = 0.529) were significantly correlated with the TOS level of the placenta. Our results support the concept that placental defective response to an oxidant stimulus plays a central role in the etiopathogenesis of preeclampsia by using the novel automated Erel method.
- Subjects
TURKEY; PLACENTA physiology; ACADEMIC medical centers; ANALYSIS of variance; ANTIOXIDANTS; COMPUTER software; STATISTICAL correlation; LONGITUDINAL method; PREECLAMPSIA; STATISTICS; DATA analysis; OXIDATIVE stress; CASE-control method
- Publication
Journal of Obstetrics & Gynaecology Research, 2011, Vol 37, Issue 4, p337
- ISSN
1341-8076
- Publication type
Article
- DOI
10.1111/j.1447-0756.2010.01346.x