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- Title
Polygenic Variation Underlying Educational Attainment and Attention-Deficit/Hyperactivity Disorder Indexes Behavior Ratings of Executive Functions in Child Psychiatry Outpatients.
- Authors
Capawana, Michael R.; Vuijk, Pieter J.; Martin, Joanna; Pollastri, Alisha R.; Forchelli, Gina A.; Woscoboinik, Georgia G.; Tremblay, Sonia L.; Wolfe, Lauren E.; Braaten, Ellen B.; Doyle, Alysa E.
- Abstract
Objective: We leveraged common genetic variation underlying ADHD, educational attainment (EA) and cognition (COG) to understand the nature of the Behavior Rating Inventory for Executive Functions (BRIEF) and its relationship to academic functioning. Method: Participants were 991 youth, ages 7 to 17, consecutively referred for neuropsychiatric evaluation. Polygenic scores (PGS) for ADHD, EA, and COG were related to the BRIEF using regression analyses. Structural equation models were used to examine the associations between the PGS, BRIEF and academic outcomes (math, reading, and special education services [EDPLAN]). Results: After modeling the PGS together, only the EA and ADHD PGS significantly associated with the BRIEF. The BRIEF partially mediated the relationships between EA PGS with math and EDPLAN and fully mediated the relationship between ADHD PGS and EDPLAN. Conclusion: Genetic data extend evidence that the BRIEF measures a construct relevant to educational success that differs from what is indexed by cognitive testing.
- Subjects
EXECUTIVE function; EDUCATIONAL attainment; ATTENTION-deficit hyperactivity disorder; CHILD psychiatry; BEHAVIOR disorders; SPECIAL education teachers
- Publication
Journal of Attention Disorders, 2024, Vol 28, Issue 5, p861
- ISSN
1087-0547
- Publication type
Article
- DOI
10.1177/10870547231219763