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- Title
An increased dose of insulin detemir improves glycaemic control and reduces body weight of Japanese patients with diabetes.
- Authors
Fujii, H.; Watanabe, Y.; Ueki, A.; Ohno, A.; Kato, M.; Kondo, K.; Takamura, H.; Takesue, M.; Nishimura, H.; Matsuda, D.; Miyakawa, T.
- Abstract
Aims: The aim of study was to evaluate the safety and efficacy of insulin detemir as a basal insulin switching from neutral protamine Hagedorn insulin (NPH) and insulin glargine in patients with diabetes on an intensive insulin therapy regimen. Methods: This 6-month multicentre, prospective, treat-to-target [glycosylated haemoglobin (HbA1c) less than 6.5%] trial included 92 people with diabetes (61 type 1, 29 type 2 and two unknown diabetes types). Detemir was administered first with fixed dose and injection times and then adapted to optimal dose after 3 months. Results: Mean HbA1c (%) of all the subjects at months 4 to 6 of the study was improved compared with month 0 (7.34 ± 0.87, 7.28 ± 0.88, 7.25 ± 0.93 vs. 7.55 ± 1.18; p < 0.05 paired t-test). However, significant improvement was seen only among the patients who had previously used NPH as a basal insulin. Twice-daily injection of basal insulin increased among people in the type 1 previously injected insulin glargine. Total insulin dose increased in the type 1 glargine group. The mean body weight change in the highest quartile body mass index (BMI) group was from 70.7 to 69.3 kg over the 6 months. Quality of life (QoL) relating to the patients' glycaemic control tended to improve without a change in frequency of hypoglycaemia. Conclusions: The results suggest that insulin detemir has a greater effect on glycaemic control in subjects with poor glycaemic control using NPH; can reduce or maintain body weight in obese patients; and obtains perceptive stability for patients with unstable glycaemic control.
- Publication
International Journal of Clinical Practice, 2010, Vol 64, Issue 11, p1512
- ISSN
1368-5031
- Publication type
Article
- DOI
10.1111/j.1742-1241.2010.02391.x