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- Title
Synthesis and Properties of 4,6-Dimethyl-5-pentyl-2-thioxo-1,2-dihydropyridine-3-carbonitrile and 3-Amino-4,6-dimethyl-5-pentylthieno[2,3-b]pyridines.
- Authors
Buryi, D. S.; Dotsenko, V. V.; Aksenov, N. A.; Aksenova, I. V.; Krivokolysko, S. G.; Dyadyuchenko, L. V.
- Abstract
The reaction of 3-pentylpentane-2,4-dione with cyanothioacetamide afforded 4,6-dimethyl-5-pentyl-2-thioxo-1,2-dihydropyridine-3-carbonitrile. Alkylation of the latter led to the formation of 2-alkylsulfanyl-4,6-dimethyl-5-pentylpyridine-3-carbonitriles or 3-amino-4,6-dimethyl-5-pentylthieno[2,3-b]pyridines, depending on the alkylating agent and reaction conditions. The structures of the key compounds were proved by 2D NMR spectroscopy and X-ray analysis. Biological activity of the synthesized compounds was evaluated in silico. Some compounds were experimentally found to stimulate growth of sunflower seedlings.
- Subjects
ALKYLATING agents; NUCLEAR magnetic resonance spectroscopy; X-ray spectroscopy; ALKYLATION; IMIDAZOPYRIDINES; SUNFLOWERS
- Publication
Russian Journal of General Chemistry, 2019, Vol 89, Issue 8, p1575
- ISSN
1070-3632
- Publication type
Article
- DOI
10.1134/S1070363219080061