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- Title
Comparison of the Effect of Sertraline and Nortriptyline on the Quality of Life of Stroke Patients.
- Authors
Shabani, Mina
- Abstract
Introduction: Stroke is a neurological disorder that causes the loss of quality of life of patients, in acute cases, and depression at varying degrees in these patients. Serotonin reuptake inhibitors and triangular antidepressants used to treat depression and improve the quality of life of these patients. The present study was conducted to compare the effects of sertraline and nortriptyline on various aspects of quality of life and prevention of depression in stroke patients. Materials and Methods: The present randomized clinical trial was conducted on 55 patients with the first episode of stroke admitted in the department of Neurosurgery of Vali-e-Asr Hospital in Zanjan with no history of depression in the first place; the subjects were randomly divided into two groups and they were treated with sertraline or nortriptyline for 6 months. Two variables of the rate of depression at the end of the study (Beck questionnaire) and dimensions of quality of life before and after the study (Nottingham Quality of Life Questionnaire) were investigated. Results: The mean of all dimensions of quality of life and its overall quality improved after treatment with sertraline and nortriptyline. At the end of the study 17.9% of patients treated with sertraline and 37% of patients treated with noreptyline developed moderate to severe depression (P value = 0.23). Conclusions and recommendations: Administration of sertraline and nortriptyline improved the quality of life dimensions and its total rate in patients. Also, the two medicines were compared in terms of the effects of depression prevention, both of which turned out to be quite effective. Despite being effective, these two medicines were not statistically significant in comparison to each other; they were, rather, clinically significant and the effect of sertraline turned out to be stronger than nortriptyline; therefore, both medicines are recommended to treat cases of depression depending on the conditions of the patients.
- Subjects
NOTTINGHAM (England); STROKE patients; QUALITY of life; SERTRALINE; SEROTONIN uptake inhibitors; MULTI-infarct dementia
- Publication
Iranian Journal of Psychiatry & Behavioral Sciences / Progress in Psychiatry & Behavioral Sciences, 2018, p170
- ISSN
1735-8639
- Publication type
Article