We found a match
Your institution may have rights to this item. Sign in to continue.
- Title
Self-Report Measures in the Assessment of Antiretroviral Medication Adherence: Comparison with Medication Possession Ratio and HIV Viral Load.
- Authors
Kabore, Lassane; Muntner, Paul; Chamot, Eric; Zinski, Anne; Burkholder, Greer; Mugavero, Michael J
- Abstract
<bold>Background: </bold>Adherence is a major determinant of the effectiveness of antiretroviral therapy (ART). We determined the association between self-reported adherence (SRA) and medication possession ratio (MPR), a pharmacy-based adherence measure, and their respective associations with viral load.<bold>Methods: </bold>Adherence to ART was assessed by MPR over 6 months and by self-report which included a question with a Likert-type scale response, a visual analogue scale (VAS), and an inquiry about the last time the patients skipped any prescribed medications.<bold>Results: </bold>Taking MPR as the "gold standard," all 3 SRA measures displayed high specificity but low sensitivity. The prevalence ratio (95% confidence interval) for viral load ≥50 copies/mL was 2.19 (1.07-4.50) for MPR <90%, 1.98 (1.04-3.78) for poor/fair/good versus excellent/very good ability to take antiretroviral drugs, 1.47 (0.79-2.75) for skipping medications within the past 2 weeks, and 2.51 (1.39-4.53) for VAS <95%.<bold>Conclusion: </bold>These data suggest various SRA measures hold clinical value in screening for poor ART adherence.
- Subjects
PATIENT compliance; SELF-evaluation; ANTIRETROVIRAL agents; UNIVERSITY of Alabama at Birmingham; MEDICAL research
- Publication
Journal of the International Association of Providers of AIDS Care, 2015, Vol 14, Issue 2, p156
- ISSN
2325-9582
- Publication type
journal article
- DOI
10.1177/2325957414557263