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- Title
Analysis of differential miRNA expression in primary tumor and stroma of colorectal cancer patients.
- Authors
Della Vittoria Scarpati, Giuseppina; Calura, Enrica; Di Marino, Mariacristina; Romualdi, Chiara; Beltrame, Luca; Malapelle, Umberto; Troncone, Giancarlo; De Stefano, Alfonso; Pepe, Stefano; De Placido, Sabino; D'Incalci, Maurizio; Marchini, Sergio; Carlomagno, Chiara
- Abstract
Microarray technology was used to profile miRNA expression in primary tumor and stromal tissue from paraffin embedded material of 51 patients with colorectal cancer. 26 miRNAs resulted differentially expressed with at least 2-fold change in tumor tissue with respect to stroma (16 more expressed in the tumor and 10 more expressed in the stroma). 10/26 were confirmed as differentially expressed at qRTPCR: miR-200c-3p, miR-141-3p, miR-200b-3p, miR-200a-3p, miR-1246, miR-92a-3p, miR-194-5p, miR-192-5p, miR-3651-5p, and miR-574-3p. No significant association was found between miRNA expressions and stage at diagnosis, site of primary tumor, first site of metastasis, progression-free, or overall survival.
- Publication
BioMed Research International, 2014, Vol 2014, p840921
- ISSN
2314-6133
- Publication type
journal article
- DOI
10.1155/2014/840921