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- Title
Influenza Virus Specific CD<sup>8+</sup> T Cells Exacerbate Infection Following High Dose Influenza Challenge of Aged Mice.
- Authors
Parzych, E. M.; DiMenna, L. J.; Latimer, B. P.; Small, J. C.; Kannan, S.; Manson, B.; Lasaro, M. O.; Wherry, E. J.; Ertl, H. C.
- Abstract
Influenza viruses cause severe illnesses and death, mainly in the aged population. Protection afforded by licensed vaccines through subtype-specific neutralizing antibodies is incomplete, especially when the vaccine antigens fail to closely match those of the circulating viral strains. Efforts are underway to generate a so-called universal influenza vaccine expressing conserved viral sequences that induce broad protection to multiple strains of influenza virus through the induction of CD8+ T cells. Here we assess the effect of a potent antiviral CD8+ T cell response on influenza virus infection of young and aged mice. Our results show that CD8+ T cell-inducing vaccines can provide some protection to young mice, but they exacerbate influenza virus-associated disease in aged mice, causing extensive lung pathology and death.
- Publication
BioMed Research International, 2013, Vol 2013, p1
- ISSN
2314-6133
- Publication type
Article
- DOI
10.1155/2013/876314