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- Title
Importance of the Caspase Cleavage Site in Amyloid-β Protein Precursor.
- Authors
Bredesen, Dale E.; John, Varghese; Galvan, Veronica
- Abstract
Reports from multiple laboratories have now been published analyzing the critical nature of the caspase cleavage site of amyloid-β protein precursor (AβPP) for cell death induction, synaptic loss, hippocampal atrophy, long-term potentiation, memory loss, neophobia, and other aspects of the Alzheimer's phenotype. Here we review the results and implications of these studies for the understanding of Alzheimer's disease pathophysiology and the potential development of therapeutics that target this site in AβPP.
- Subjects
ALZHEIMER'S disease; AMYLOID beta-protein; PEPTIDES; LABORATORY mice; CELL death; MEMORY loss; PATHOLOGICAL physiology
- Publication
Journal of Alzheimer's Disease, 2010, Vol 22, Issue 1, p57
- ISSN
1387-2877
- Publication type
Article
- DOI
10.3233/JAD-2010-100537