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- Title
Lipid-Laden Macrophages in Pulmonary Diseases.
- Authors
Zhu, Yin; Choi, Dooyoung; Somanath, Payaningal R.; Zhang, Duo
- Abstract
Pulmonary surfactants play a crucial role in managing lung lipid metabolism, and dysregulation of this process is evident in various lung diseases. Alternations in lipid metabolism lead to pulmonary surfactant damage, resulting in hyperlipidemia in response to lung injury. Lung macrophages are responsible for recycling damaged lipid droplets to maintain lipid homeostasis. The inflammatory response triggered by external stimuli such as cigarette smoke, bleomycin, and bacteria can interfere with this process, resulting in the formation of lipid-laden macrophages (LLMs), also known as foamy macrophages. Recent studies have highlighted the potential significance of LLM formation in a range of pulmonary diseases. Furthermore, growing evidence suggests that LLMs are present in patients suffering from various pulmonary conditions. In this review, we summarize the essential metabolic and signaling pathways driving the LLM formation in chronic obstructive pulmonary disease, pulmonary fibrosis, tuberculosis, and acute lung injury.
- Subjects
FOAM cells; LUNG diseases; PULMONARY fibrosis; MECONIUM aspiration syndrome; SMOKING; CHRONIC obstructive pulmonary disease
- Publication
Cells (2073-4409), 2024, Vol 13, Issue 11, p889
- ISSN
2073-4409
- Publication type
Article
- DOI
10.3390/cells13110889