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- Title
Chromosome Tug of War: Dicentric Chromosomes and the Centromere Strength Hypothesis.
- Authors
Hill, Hunter J.; Golic, Kent G.
- Abstract
It has been 70 years since the concept of varied centromere strengths was introduced based on the behavior of dicentric chromosomes. One of the key conclusions from those early experiments was that some centromeres could pull with sufficient force to break a dicentric chromosome bridge, while others could not. In the ensuing decades there have been numerous studies to characterize strengths of the various components involved, such as the spindle, the kinetochore, and the chromosome itself. We review these various measurements to determine if the conclusions about centromere strength are supported by current evidence, with special attention to characterization of Drosophila melanogaster kinetochores upon which the original conclusions were based.
- Subjects
CHROMOSOME segregation; KINETOCHORE; DROSOPHILA melanogaster; CENTROMERE; CHROMOSOMES
- Publication
Cells (2073-4409), 2022, Vol 11, Issue 22, p3550
- ISSN
2073-4409
- Publication type
Article
- DOI
10.3390/cells11223550