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- Title
Accuracy Assessment of Five Equations Used for Estimating the Glomerular Filtration Rate in Korean Adults.
- Authors
Tae-Dong Jeong; Eun-Jung Cho; Woochang Lee; Sail Chun; Ki-Sook Hong; Won-Ki Min
- Abstract
Background: We aimed to assess the performance of the five creatinine-based equations commonly used for estimates of the glomerular filtration rate (eGFR), namely, the creatinine- based Chronic Kidney Disease Epidemiology Collaboration (CKD-EPIcr), Asian CKDEPI, revised Lund-Malmö (revised LM), full age spectrum (FAS), and Korean FAS equations, in the Korean population. Methods: A total of 1,312 patients, aged 20 yr and above who underwent 51Cr-EDTA GFR measurements (mGFR), were enrolled. The bias (eGFR-mGFR) and precision (root mean square error [RMSE]) were calculated. The accuracy (P30) of four eGFR equations was compared to that of the CKD-EPIcr equation. P30 was defined as the percentage of patients whose eGFR was within±30% of the mGFR. Results: The mean bias (mL·min-1·1.73 m-2) of the five eGFR equation was as follows: CKD-EPIcr, -0.6; Asian CKD-EPI, 2.7; revised LM, -6.5; FAS, -2.5; and Korean FAS, -0.2. The bias of the Asian CKD-EPI, revised LM, and FAS equations showed a significant difference from zero (P <0.001). The RMSE values were as follows: CKD-EPIcr, 15.6; Asian CKD-EPI, 15.6; revised LM, 17.9; FAS, 16.3; and Korean FAS, 15.8. There were no significant differences in the P30 except for the Asian CKD-EPI equation: CKD-EPIcr, 76.6%; Asian CKD-EPI, 74.7%; revised LM, 75.8%; FAS, 76.0%; and Korean FAS, 75.8%. Conclusions: The CKD-EPIcr and Korean FAS equations showed equivalent analytical and clinical performances in the Korean adult population.
- Subjects
SOUTH Korea; GLOMERULAR filtration rate; STANDARD deviations; PUBLIC health; KIDNEY diseases; MASS spectrometry; PATIENTS
- Publication
Annals of Laboratory Medicine, 2017, Vol 37, Issue 5, p371
- ISSN
2234-3806
- Publication type
Article
- DOI
10.3343/alm.2017.37.5.371