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- Title
Human Leukocyte Antigen-C Genotype and Killer Immunoglobulin-like Receptor-Ligand Matching in Korean Living Donor Liver Transplantation.
- Authors
Hyeyoung Lee; Ki Hyun Park; Hye Sun Park; Ji Hyeong Ryu; Jihyang Lim; Yonggoo Kim; Gun Hyung Na; Dong Goo Kim; Eun-Jee Oh
- Abstract
Background: The interaction between killer immunoglobulin-like receptors (KIRs) and HLA class I regulates natural killer (NK) cell cytotoxicity and function. The impact of NK cell alloreactivity through KIR in liver transplantation remains unelucidated. Since the frequency of HLA-C and KIR genotypes show ethnic differences, we assessed the impact of HLA-C, KIR genotype, or KIR-ligand mismatch on the allograft outcome of Korean liver allografts. Methods: One hundred eighty-two living donor liver transplant patients were studied. Thirtyfive patients (19.2%) had biopsy-confirmed acute rejection (AR), and eighteen (9.9%) had graft failure. The HLA-C compatibility, KIR genotypes, ligand-ligand, and KIR-ligand matching was retrospectively investigated for association with allograft outcomes. Results: Homozygous C1 ligands were predominant in both patients and donors, and frequency of the HLA-C2 allele in Koreans was lower than that in other ethnic groups. Despite the significantly lower frequency of the HLA-C2 genotype in Koreans, donors with at least one HLA-C2 allele showed higher rates of AR than donors with no HLA-C2 alleles (29.2% vs 15.7%, P =0.0423). Although KIR genotypes also showed ethnic differences, KIR genotypes and the number of activating KIR/inhibitory KIR were not associated with the allograft outcome. KIR-ligand mismatch was expected in 31.6% of Korean liver transplants and had no impact on AR or graft survival. Conclusions: This study could not confirm the clinical impact of KIR genotypes and KIRligand mismatch. However, we demonstrated that the presence of HLA-C2 allele in the donor influenced AR of Korean liver allografts.
- Subjects
HLA histocompatibility antigens; GENOTYPES; IMMUNOGLOBULINS; RECEPTOR-ligand complexes; LIVER transplantation; KOREANS; ORGAN donors; HEALTH
- Publication
Annals of Laboratory Medicine, 2017, Vol 37, Issue 1, p45
- ISSN
2234-3806
- Publication type
Article
- DOI
10.3343/alm.2017.37.1.45