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- Title
EP06.13: Trisomy 21 and brain pathologies.
- Authors
Binder, J.; Palmrich, P.; Ulm, B.; Bettelheim, D.; Gruber, G.M.; Kasprian, G.; Prayer, D.
- Abstract
The aim of this study was to evaluate the brain of fetuses affected by trisomy 21 using fetal magnetic resonance imaging (fetal MRI). 11 fetuses (52.4%) had normal brains on fetal MRI scans and the following different brain abnormalities were present in the remaining 10 fetuses (47.6%): ventriculomegaly and/or asymmetry of the lateral ventricles in 6 (28.6%), corpus callosum anomalies in 4 (19%), small cerebellar diameter in 3 (14.3%) and wide extracerebral fluid spaces in 3 (14.3%). Almost 50% of fetuses with trisomy 21 show a variety of different brain pathologies on fetal MRI, which could attribute to the differences in clinical neurological presentation reported in these children.
- Subjects
DOWN syndrome; BRAIN diseases; FETAL MRI
- Publication
Ultrasound in Obstetrics & Gynecology, 2019, Vol 54, p264
- ISSN
0960-7692
- Publication type
Article
- DOI
10.1002/uog.21213