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- Title
Urine DNA for monitoring chemoradiotherapy response in muscle‐invasive bladder cancer: a pilot study.
- Authors
Gordon, Naheema S.; Baxter, Laura A.; Goel, Anshita; Arnold, Roland; Kaur, Baljit; Liu, Wenyu; Pirrie, Sarah J.; Hussain, Syed; Viney, Richard; Ford, Daniel; Zarkar, Anjali; Wood, Mary A.; Mitin, Timur; Thompson, Reid F.; James, Nicholas D.; Ward, Douglas G.; Bryan, Richard T.
- Abstract
We undertook a pilot study to evaluate whether measuring common BC-associated mutations in urinary DNA can contribute to the monitoring of treatment responses in patients with organ-confined MIBC treated with curative intent. Abbreviations BC bladder cancer cpDNA chloroplast DNA MIBC muscle-invasive bladder cancer SNV single-nucleotide variant VAF variant allele frequency Accumulating evidence implies the utility of DNA-based urine biomarkers for initial detection of bladder cancer (BC) and surveillance of non-muscle-invasive BC [1,2]. In summary, two out of the four patients who relapsed (three local, one distant, 3-9 months after completing treatment) had undetectable urinary VAFs on treatment completion.
- Subjects
BLADDER cancer; CANCER invasiveness; CHEMORADIOTHERAPY; DNA; PILOT projects; URINE
- Publication
BJU International, 2022, Vol 129, Issue 1, p32
- ISSN
1464-4096
- Publication type
Article
- DOI
10.1111/bju.15589