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- Title
Inflammatory response: The target for treating hyperpigmentation during the repair of a burn wound.
- Authors
Chi Zhong; Geao Liang; Peiting Li; Ke Shi; Fuyin Li; Jianda Zhou; Dan Xu
- Abstract
Hyperpigmentation is a common complication in patients with burn injuries during wound healing; however, the mechanisms underlying its occurrence and development remain unclear. Recently, postinflammatory hyperpigmentation (PIH) was found to result from overproduction of melanin. Local or systemic inflammatory responses are often observed in patients who develop hyperpigmentation. However, we lack studies on the relationship between PIH and burn injury. Therefore, we comprehensively reviewed the existing literature on the melanogenesis of the skin, inflammatory mechanisms in pigmentation, and local or systemic alteration in inflammatory cytokines in patients suffering from burn trauma to elucidate the relationship between PIH and burn injury. We believe that this review will guide further research on regulating melanin production in the burn management process.
- Subjects
INFLAMMATION; WOUND healing; HYPERPIGMENTATION; WOUND infections; PRODUCTION management (Manufacturing); BURN patients
- Publication
Frontiers in Immunology, 2023, Vol 14, p1
- ISSN
1664-3224
- Publication type
Article
- DOI
10.3389/fimmu.2023.1009137