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- Title
Metal-Organic Framework Co( D-Cam)<sub>1/2</sub>(bdc)<sub>1/2</sub>(tmdpy) for Improved Enantioseparations on a Chiral Cyclodextrin Stationary Phase in Gas Chromatography.
- Authors
Liu, Hong; Xie, Sheng‐Ming; Ai, Ping; Zhang, Jun‐Hui; Zhang, Mei; Yuan, Li‐Ming
- Abstract
Initial efforts to combine a chiral metal-organic framework (MOF), Co( D-Cam)1/2(bdc)1/2(tmdpy) ( D-Cam= D-camphoric acid, bdc=1,4-benzenedicarboxylic acid, tmdpy=4,4′-trimethylenedipyridine), with peramylated β-cyclodextrins to investigate whether the use of a MOF can enhance enantioseparations on a cyclodextrin stationary phase are reported. Compared with columns of peramylated β-cyclodextrin incorporated in a MOF containing sodium chloride, the column of peramylated β-cyclodextrin+MOF shows excellent selectivity for the recognition of racemates, and higher resolutions are achieved on the peramylated β-cyclodextrin+MOF stationary phase. Experimental results indicate that the use of Co( D-Cam)1/2(bdc)1/2(tmdpy) can improve enantioseparations on peramylated β-cyclodextrins. This is the first report that chiral MOFs can improve enantioseparations on a chiral stationary phase for chromatography.
- Subjects
METAL-organic frameworks; CYCLODEXTRINS; CHIRAL stationary phases; GAS chromatography; SEPARATION of enantiomers; CAMPHORIC acid
- Publication
ChemPlusChem, 2014, Vol 79, Issue 8, p1103
- ISSN
2192-6506
- Publication type
Article
- DOI
10.1002/cplu.201402067