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- Title
Multicentric Glioblastoma Multiforme in a Patient with BRCA-1 Invasive Breast Cancer.
- Authors
Elmariah, Sarina B.; Huse, Jason; Mason, Bernard; LeRoux, Peter; Lustig, Robert A.
- Abstract
Breast cancer is the most common cancer in women. Germline mutations in BRCA-1 and BRCA-2 significantly increase the risk of developing breast and ovarian cancers, and are also associated with an increased incidence of primary cancers at other sites. We report the case of a 46-year-old woman previously treated for ductal adenocarcinoma of the breast with BRCA-1 who subsequently was diagnosed with multicentric glioblastoma multiforme (GBM) in the right temporal and right occipital lobes. We briefly discuss the incidence of BRCA-1 mutations in breast cancer as well as other primary neoplasms and consider potential mechanisms shared in the pathogenesis of breast and glial tumors.
- Subjects
BREAST cancer; CANCER in women; GENETIC mutation; OVARIAN diseases; ADENOCARCINOMA; GLIOBLASTOMA multiforme; OCCIPITAL lobe; CARCINOGENESIS
- Publication
Breast Journal, 2006, Vol 12, Issue 5, p470
- ISSN
1075-122X
- Publication type
Article
- DOI
10.1111/j.1075-122X.2006.00307.x