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- Title
Gut-directed hypnotherapy significantly augments clinical remission in quiescent ulcerative colitis.
- Authors
Keefer, L.; Taft, T. H.; Kiebles, J. L.; Martinovich, Z.; Barrett, T. A.; Palsson, O. S.
- Abstract
Background Psychotherapy is not routinely recommended for in ulcerative colitis ( UC). Gut-directed hypnotherapy ( HYP) has been linked to improved function in the gastrointestinal tract and may operate through immune-mediated pathways in chronic diseases. Aims To determine the feasibility and acceptability of HYP and estimate the impact of HYP on clinical remission status over a 1-year period in patients with an historical flare rate of 1.3 times per year. Methods A total of 54 patients were randomised at a single site to seven sessions of gut-directed HYP ( n = 26) or attention control ( CON; n = 29) and followed for 1 year. The primary outcome was the proportion of participants in each condition that had remained clinically asymptomatic (clinical remission) through 52 weeks post treatment. Results One-way analysis of variance comparing HYP and CON subjects on number of days to clinical relapse favoured the HYP condition [ F = 4.8 (1, 48), P = 0.03] by 78 days. Chi-squared analysis comparing the groups on proportion maintaining remission at 1 year was also significant [ χ2(1) = 3.9, P = 0.04], with 68% of HYP and 40% of CON patients maintaining remission for 1 year. There were no significant differences between groups over time in quality of life, medication adherence, perceived stress or psychological factors. Conclusion This is the first prospective study that has demonstrated a significant effect of a psychological intervention on prolonging clinical remission in patients with quiescent ulcerative colitis (Clinical Trial # NCT00798642).
- Subjects
PSYCHOTHERAPY; GASTROINTESTINAL system; CHRONIC diseases; ULCERATIVE colitis; GUT microbiome; COLON diseases
- Publication
Alimentary Pharmacology & Therapeutics, 2013, Vol 38, Issue 7, p761
- ISSN
0269-2813
- Publication type
Article
- DOI
10.1111/apt.12449