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- Title
Hepatic steatosis and insulin resistance are associated with serum imbalance of adiponectin/tumour necrosis factor- α in chronic hepatitis C patients.
- Authors
DURANTE‐MANGONI, E.; ZAMPINO, R.; MARRONE, A.; TRIPODI, M.‐F.; RINALDI, L.; RESTIVO, L.; CIOFFI, M.; RUGGIERO, G.; ADINOLFI, L. E.
- Abstract
Background Steatosis and insulin resistance (IR) have a pathogenic role in chronic hepatitis C (HCV). Adipocytokines balance modulates hepatic lipid content and IR. Aim To evaluate serum adipocytokines and relationship with virological, histological and metabolic parameters in chronic HCV. Methods Adiponectin and tumour necrosis factor- α (TNF-α) levels, HCV genotypes, HCV-RNA, IR (HOMA-IR), body mass index and liver steatosis and fibrosis were assessed in 161 non-diabetic chronic HCV patients. Results Chronic HCV patients with steatosis showed lower serum adiponectin levels and higher levels of TNF-α, HOMA, alanine aminotransferase, γ-glutamiltransferase and Histological Activity Index (HAI) and fibrosis scores. Low adiponectin levels were independently associated with grades of steatosis and HOMA-IR. Higher tumour necrosis factor- α levels were observed in patients with low adiponectin levels. The extension of steatosis was inversely correlated with adiponectin levels. A correlation between grade of steatosis with HOMA-IR and fibrosis was observed. HCV genotype 3-infected patients showed lower adiponectin levels than those with other genotypes. An independent predictor of low adiponectin levels in genotype 3 infection was the extension of steatosis. Liver fibrosis score was associated with steatosis, HAI and age. Conclusions Chronic HCV patients with steatosis showed a serum adiponectin/TNF-α imbalance that is associated with IR. Reduced adiponectin levels may be involved in the pathogenesis of steatosis, which in turn accelerates progression of fibrosis in chronic HCV.
- Subjects
INSULIN resistance; HEPATITIS C virus; ALANINE aminotransferase; GLUTATHIONE transferase; TUMOR necrosis factors; CYSTIC fibrosis; LIPID metabolism; ADIPOSE tissues
- Publication
Alimentary Pharmacology & Therapeutics, 2006, Vol 24, Issue 9, p1349
- ISSN
0269-2813
- Publication type
Article
- DOI
10.1111/j.1365-2036.2006.03114.x