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- Title
Clinical characteristics of fulminant-type autoimmune hepatitis: an analysis of eleven cases.
- Authors
MIYAKE, Y.; IWASAKI, Y.; TERADA, R.; ONISHI, T.; OKAMOTO, R.; SAKAI, N.; SAKAGUCHI, K.; SHIRATORI, Y.
- Abstract
Background Although a few adult cases of fulminant-type autoimmune hepatitis have been reported, their clinical features and prognosis have remained uncertain. Aim To assess the clinical features and prognosis of patients with fulminant-type autoimmune hepatitis. Methods Eleven patients (10%) diagnosed with fulminant-type autoimmune hepatitis in accordance with the 1999 criteria of the International Autoimmune Hepatitis Group were analysed. Results All 11 patients were female, with a median age of 53 years. Five patients survived without liver transplantation, one received a liver transplantation, and five died without liver transplantation. Nine patients (82%) survived for 2 weeks or more following diagnosis, without liver transplantation. Except for the patient receiving a liver transplantation, serum total bilirubin levels measured during the clinical course were significantly higher in non-survivors than in survivors, although the accompanying serum alanine aminotransferase levels measured for the two groups were similar. Most significantly, serum total bilirubin levels in non-survivors worsened during days 8–15, while levels in survivors improved during the same period. Conclusions The short-term prognosis for patients with fulminant-type autoimmune hepatitis may be good. However, patients whose serum total bilirubin levels worsen during days 8–15 should be considered for liver transplantation.
- Subjects
CHRONIC active hepatitis; LIVER transplantation; HEPATIC coma; ULTRASONIC imaging; AUTOIMMUNE diseases; LIVER diseases; BLOOD plasma
- Publication
Alimentary Pharmacology & Therapeutics, 2006, Vol 23, Issue 9, p1347
- ISSN
0269-2813
- Publication type
Article
- DOI
10.1111/j.1365-2036.2006.02894.x