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- Title
CDX2 is mutated in a colorectal cancer with normal APC/β-catenin signaling.
- Authors
da Costa, Luis T; He, Tong-Chuan; Yu, Jian; Sparks, Andrew B; Morin, Patrice J; Polyak, Kornelia; Laken, Steve; Vogelstein, Bert; Kinzler, Kenneth W
- Abstract
The majority of human colorectal cancers have elevated β-catenin/TCF regulated transcription due to either inactivating mutations of the APC tumor suppressor gene or activating mutations of β-catenin. Surprisingly, one commonly used colorectal cancer cell line was found to have intact APC and β-catenin and no demonstrable β-catenin/TCF regulated transcription. However, this line did possess a truncating mutation in one allele of CDX2, a gene whose inactivation has recently been shown to cause colon tumorigenesis in mice. Expression of CDX2 was found to be induced by restoring expression of wild type APC in a colorectal cancer cell line. These findings raise the intriguing possibility that CDX2 contributes to APC's tumor suppressive effects.
- Subjects
COLON cancer; TUMOR suppressor genes
- Publication
Oncogene, 1999, Vol 18, Issue 35, p5010
- ISSN
0950-9232
- Publication type
Article
- DOI
10.1038/sj.onc.1202872