We found a match
Your institution may have rights to this item. Sign in to continue.
- Title
Rac1 is required for the formation of three germ layers during gastrulation.
- Authors
Sugihara, Kazuhiro; Nakatsuji, Norio; Nakamura, Kenji; Nakao, Kazuki; Hashimoto, Ryuju; Otani, Hiroki; Sakagami, Hiroyuki; Kondo, Hisatake; Nozawa, Shiro; Aiba, Atsu; Katsuki, Motoya
- Abstract
The Rac1, a member of the Rho family proteins, regulates actin organization of cytoskeleton and cell adhesion. We used genetic analysis to elucidate the role of Rac1 in mouse embryonic development. The rac1 deficient embryos showed numerous cell deaths in the space between the embryonic ectoderm and endoderm at the primitive streak stage. Investigation of the primary epiblast culture isolated from rac1 deficient embryos indicated that Rac1 is involved in lamellipodia formation, cell adhesion and cell migration in vivo. These results suggest that Rac1-mediated cell adhesion is essential for the formation of three germ layers during gastrulation.
- Subjects
PROTEINS; ACTIN; CYTOSKELETON; CELL adhesion; CELL death
- Publication
Oncogene, 1998, Vol 17, Issue 26, p3427
- ISSN
0950-9232
- Publication type
Article
- DOI
10.1038/sj.onc.1202595