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- Title
Association between long noncoding RNA taurine‐upregulated gene 1 and microRNA‐377 in vitiligo.
- Authors
Alhelf, Maha; Rashed, Laila A.; Ragab, Noura; Elmasry, Maha F.
- Abstract
Background: Taurine‐upregulated gene 1 (TUG1) is one of the long noncoding RNAs (lncRNAs) that plays a role in melanogenesis. MicroRNA‐377 (miRNA‐377) is a conserved noncoding RNA that regulates angiogenesis and promotes oxidative stress. Peroxisome proliferator‐activated receptors (PPARs) are components of the nuclear hormone receptor superfamily. PPAR‐γ activators stimulate melanogenesis. Interleukin (IL)‐17 has been implicated in the pathogenesis of several immunological diseases. This work aimed at detecting the expression levels of lncRNA TUG1, miRNA‐377, PPAR‐γ, and IL‐17 among vitiligo subjects and to investigate their possible role in the pathogenesis of vitiligo. Methods: This study was conducted on 30 healthy controls and 30 vitiligo patients. LncRNA TUG1 and miRNA‐377 were detected in serum by real‐time polymerase chain reaction (PCR). Also, expressions of PPAR‐γ and IL‐17 were assessed in tissue by real‐time PCR. Results: LncRNA TUG1 and PPAR‐γ levels were significantly downregulated in the vitiligo group compared with the control group. On the other hand, miRNA‐377 and IL‐17 were significantly upregulated in the vitiligo group compared with the control group. Conclusion: This study demonstrated the dysregulated expressions of lncRNA TUG1 and miRNA‐377 in patients with vitiligo suggesting that both contributed to the pathogenesis of vitiligo that might be through PPAR‐γ downregulation and IL‐17 upregulation.
- Subjects
VITILIGO; LINCRNA; GENETIC code; NUCLEAR receptors (Biochemistry); PEROXISOME proliferator-activated receptors; NON-coding RNA; IMMUNOLOGIC diseases
- Publication
International Journal of Dermatology, 2022, Vol 61, Issue 2, p199
- ISSN
0011-9059
- Publication type
Article
- DOI
10.1111/ijd.15669