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- Title
Altered Metabolic Phenotypes and Hypothalamic Neuronal Activity Triggered by Sodium-Glucose Cotransporter 2 Inhibition (Diabetes Metab J 2023;47: 784-95).
- Authors
Ho Gyun Lee; Il Hyeon Jung; Byong Seo Park; Hye Rim Yang; Kwang Kon Kim; Thai Hien Tu; Jung-Yong Yeh; Sewon Lee; Sunggu Yang; Byung Ju Lee; Jae Geun Kim; Il Seong Nam-Goong
- Abstract
The article titled "Altered Metabolic Phenotypes and Hypothalamic Neuronal Activity Triggered by Sodium-Glucose Cotransporter 2 Inhibition" discusses the effects of sodium-glucose cotransporter 2 (SGLT2) inhibitors on metabolic phenotypes and hypothalamic neuronal activity. The authors address concerns about the absence of comprehensive metabolic characterization, particularly in mice on a high-fat diet. They also acknowledge the complexity of drug interactions and the need for further research to understand the mechanisms by which SGLT2 inhibitors affect the central nervous system. The authors express their appreciation for the feedback and emphasize the importance of ongoing research in precision medicine.
- Subjects
DAPAGLIFLOZIN; DIABETES; GLUCAGON-like peptide-1 receptor; TYPE 2 diabetes; PHENOTYPES
- Publication
Diabetes & Metabolism Journal, 2024, Vol 48, Issue 1, p159
- ISSN
2233-6079
- Publication type
Article
- DOI
10.4093/dmj.2022.0458