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- Title
Multi-trait discovery and fine-mapping of lipid loci in 125,000 individuals of African ancestry.
- Authors
Kamiza, Abram Bunya; Touré, Sounkou M.; Zhou, Feng; Soremekun, Opeyemi; Cissé, Cheickna; Wélé, Mamadou; Touré, Aboubacrine M.; Nashiru, Oyekanmi; Corpas, Manuel; Nyirenda, Moffat; Crampin, Amelia; Shaffer, Jeffrey; Doumbia, Seydou; Zeggini, Eleftheria; Morris, Andrew P.; Asimit, Jennifer L.; Chikowore, Tinashe; Fatumo, Segun
- Abstract
Most genome-wide association studies (GWAS) for lipid traits focus on the separate analysis of lipid traits. Moreover, there are limited GWASs evaluating the genetic variants associated with multiple lipid traits in African ancestry. To further identify and localize loci with pleiotropic effects on lipid traits, we conducted a genome-wide meta-analysis, multi-trait analysis of GWAS (MTAG), and multi-trait fine-mapping (flashfm) in 125,000 individuals of African ancestry. Our meta-analysis and MTAG identified four and 14 novel loci associated with lipid traits, respectively. flashfm yielded an 18% mean reduction in the 99% credible set size compared to single-trait fine-mapping with JAM. Moreover, we identified more genetic variants with a posterior probability of causality >0.9 with flashfm than with JAM. In conclusion, we identified additional novel loci associated with lipid traits, and flashfm reduced the 99% credible set size to identify causal genetic variants associated with multiple lipid traits in African ancestry. There have been few genome-wide association studies that analyze multiple lipid traits simultaneously, especially in individuals of African ancestry. To address this, the authors performed a multi-trait analysis of GWAS along with fine-mapping to find new genetic loci associated with lipid traits in individuals of African ancestry.
- Subjects
GENOME-wide association studies; LOCUS (Genetics); GENETIC variation; GENEALOGY; LIPID analysis; MICROSATELLITE repeats; LIPIDS
- Publication
Nature Communications, 2023, Vol 14, Issue 1, p1
- ISSN
2041-1723
- Publication type
Article
- DOI
10.1038/s41467-023-41271-0