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- Title
GLP-1 Relaxes Rat Coronary Arteries by Enhancing ATP-Sensitive Potassium Channel Currents.
- Authors
Xiong, Qian-Feng; Fan, Shao-Hua; Li, Xue-Wen; Niu, Yu; Wang, Jing; Zhang, Xin; Chen, Yi-Fan; Shi, Ya-Wei; Zhang, Li-Hui
- Abstract
GLP-1 is a new type of antidiabetic agent that possesses many beneficial effects. Although its cardiovascular actions have been widely examined, little is known about GLP-1's effects on the rat coronary artery (RCA) or about the mechanisms underpinning these effects. Here, we report that GLP-1 inhibits depolarization- or thromboxane receptor agonist (U46619)-induced RCA contraction in a dosage-dependent manner. Vasorelaxation was attenuated by denuding the endothelium, L-NAME (nitric oxide synthase inhibitor), and glyburide (KATP channel blocker) but was not affected by indomethacin (cyclooxygenase inhibitor), iberiotoxin [Ca2+-activated K+ channel (KCa) blocker], or 4-aminopyridine (KV channel blocker). Furthermore, GLP-1 increased outward K+ currents by enhancing the KATP channel in rat coronary arterial smooth muscle cells (RCASMCs). These results show that GLP-1 is an endothelial-dependent vasospasmolytic agent in the RCA and imply that the relaxant effect is regulated by enhancing KATP rather than KV or KCa currents in RCASMCs.
- Subjects
AMINOPYRIDINES; ANIMAL experimentation; VASODILATION; CELL receptors; CORONARY arteries; ENDOTHELIUM; HYPOGLYCEMIC agents; HYPOGLYCEMIC sulfonylureas; INDOMETHACIN; MUSCLE contraction; RATS; SMOOTH muscle; GLUCAGON-like peptide 1; NITRIC-oxide synthases; MEMBRANE transport proteins; PHARMACODYNAMICS
- Publication
Cardiology Research & Practice, 2019, p1
- ISSN
2090-8016
- Publication type
Article
- DOI
10.1155/2019/1968785