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- Title
A 12-Week, Single-Centre, Randomised, Double-Blind, Placebo-Controlled, Parallel-Design Clinical Trial for the Evaluation of the Efficacy and Safety of Lactiplantibacillus plantarum SKO-001 in Reducing Body Fat.
- Authors
Shin, Seon Mi; Park, Jeong-Su; Kim, Sang Back; Cho, Young Hee; Seo, Hee; Lee, Hak Sung
- Abstract
There is growing evidence linking gut microbiota to overall health, including obesity risk and associated diseases. Lactiplantibacillus plantarum SKO-001, a probiotic strain isolated from Angelica gigas, has been reported to reduce obesity by controlling the gut microbiome. In this double-blind, randomised clinical trial, we aimed to evaluate the efficacy and safety of SKO-001 in reducing body fat. We included 100 participants randomised into SKO-001 or placebo groups (1:1) for 12 weeks. Dual-energy X-ray absorptiometry was used to objectively evaluate body fat reduction. Body fat percentage (p = 0.016), body fat mass (p = 0.02), low-density lipoprotein-cholesterol levels (p = 0.025), and adiponectin levels (p = 0.023) were lower in the SKO-001 group than in the placebo group after 12 weeks of SKO-001 consumption. In the SKO-001 group, the subcutaneous fat area (p = 0.003), total cholesterol levels (p = 0.003), and leptin levels (p = 0.014) significantly decreased after 12 weeks of SKO-001 consumption compared with baseline values. Additionally, SKO-001 did not cause any severe adverse reactions. In conclusion, SKO-001 is safe and effective for reducing body fat and has the potential for further clinical testing in humans.
- Subjects
THERAPEUTIC use of probiotics; PREVENTION of obesity; PHOTON absorptiometry; ADIPOSE tissues; LEPTIN; PLACEBOS; RESEARCH funding; STATISTICAL sampling; BLIND experiment; GUT microbiome; TREATMENT effectiveness; RANDOMIZED controlled trials; DESCRIPTIVE statistics; LDL cholesterol; ADIPONECTIN; LACTOBACILLUS; GRAM-positive bacteria; OBESITY; DIETARY supplements
- Publication
Nutrients, 2024, Vol 16, Issue 8, p1137
- ISSN
2072-6643
- Publication type
Article
- DOI
10.3390/nu16081137