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- Title
Dietary Approach of Patients with Hormone-Related Cancer Based on the Glycemic Index and Glycemic Load Estimates.
- Authors
Peppa, Melpomeni; Manta, Aspasia; Mavroeidi, Ioanna; Nastos, Constantinos; Pikoulis, Emmanouil; Syrigos, Konstantinos; Bamias, Aristotelis
- Abstract
Hormone-related cancers, namely breast, endometrial, cervical, prostate, testicular, and thyroid, constitute a specific group of cancers dependent on hormone levels that play an essential role in cancer growth. In addition to the traditional risk factors, diet seems to be an important environmental factor that partially explains the steadily increased prevalence of this group of cancer. The composition of food, the dietary patterns, the endocrine-disrupting chemicals, and the way of food processing and preparation related to dietary advanced glycation end-product formation are all related to cancer. However, it remains unclear which specific dietary components mediate this relationship. Carbohydrates seem to be a risk factor for cancer in general and hormone-related cancers, in particular, with a difference between simple and complex carbohydrates. Glycemic index and glycemic load estimates reflect the effect of dietary carbohydrates on postprandial glucose concentrations. Several studies have investigated the relationship between the dietary glycemic index and glycemic load estimates with the natural course of cancer and, more specifically, hormone-related cancers. High glycemic index and glycemic load diets are associated with cancer development and worse prognosis, partially explained by the adverse effects on insulin metabolism, causing hyperinsulinemia and insulin resistance, and also by inflammation and oxidative stress induction. Herein, we review the existing data on the effect of diets focusing on the glycemic index and glycemic load estimates on hormone-related cancers.
- Subjects
FOOD habits; HORMONE-dependent tumors; THYROID gland tumors; NUTRITION; INFLAMMATION; DIET; CARBOHYDRATE content of food; GLYCEMIC index; OXIDATIVE stress; ADVANCED glycation end-products; ENDOMETRIAL tumors; TESTIS tumors; FOOD handling; CERVIX uteri tumors; BREAST tumors; PROSTATE tumors; ENDOCRINE disruptors; INSULIN resistance
- Publication
Nutrients, 2023, Vol 15, Issue 17, p3810
- ISSN
2072-6643
- Publication type
Article
- DOI
10.3390/nu15173810