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- Title
Latilactobacillus sakei Wikim0066 Protects Skin through MMP Regulation on UVB-Irradiated In Vitro and In Vivo Model.
- Authors
Park, Jeong-Yong; Lee, Ji Yeon; Kim, YongGyeong; Kang, Chang-Ho
- Abstract
Ultraviolet (UV) B exposure induces wrinkle formation, collagen fiber breakdown, and transepidermal water loss (TEWL). UVB irradiation induces the expression of mitogen-activated protein kinase (MAPK), activator protein 1 (AP-1), and nuclear factor kappa B (NF-κB), which affect the expression of matrix metalloproteinases (MMP). We confirmed the effects of Latilactobacillus sakei wikim0066 (wikim0066) on UVB-irradiated Hs68 cells and HR-1 hairless mice cells. wikim0066 restored the production of type I procollagen by regulating the expression of MMP-1 and -3, MAPK, AP-1, and NF-κB in UVB-irradiated Hs68 cells and HR-1 mice. Oral administration of wikim0066 alleviates wrinkle formation, epidermal thickness, and TEWL in UVB-irradiated HR-1 hairless mice. These results indicated that wikim0066 has the potential to prevent UVB-induced wrinkle formation.
- Subjects
SKIN disease prevention; IN vitro studies; COLLAGEN; IN vivo studies; SKIN; ANIMAL experimentation; MATRIX metalloproteinases; GENE expression; SKIN physiology; SKIN aging; LACTOBACILLUS; RADIATION injuries; MITOGEN-activated protein kinases; TRANSCRIPTION factors; EPIDERMIS; CELL lines; ULTRAVIOLET radiation; MICE
- Publication
Nutrients, 2023, Vol 15, Issue 3, p726
- ISSN
2072-6643
- Publication type
Article
- DOI
10.3390/nu15030726