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- Title
Association of Vitamin D Receptor and Vitamin D-Binding Protein Polymorphisms with Familial Breast Cancer Prognosis in a Mono-Institutional Cohort.
- Authors
Aristarco, Valentina; Johansson, Harriet; Gandini, Sara; Macis, Debora; Zanzottera, Cristina; Tolva, Gianluca; Feroce, Irene; Accornero, Chiara; Bonanni, Bernardo; Guerrieri-Gonzaga, Aliana; Serrano, Davide; Michaëlsson, Karl
- Abstract
Low 25-hydroxyvitamin D (25OHD) has been associated with an increased cancer incidence and poorer prognosis. Single nucleotide polymorphisms (SNPs) of vitamin D receptor (VDR) and vitamin D binding protein (GC gene) may interfere with vitamin D activity. This study assesses the role of VDR and GC SNPs on breast cancer (BC) recurrence and survival in a cohort of patients with a family history of breast cancer, without the pathogenic variant for BRCA1 and BRCA2. A consecutive series of patients who underwent genetic testing were genotyped for VDR and GC genes. Specifically, ApaI, FokI, TaqI, BsmI and rs2282679, rs4588, rs7041 SNPs were determined. A total of 368 wild type (WT) patients with BC were analyzed for VDR and GC SNPs. The GC rs2282679 minor allele was significantly associated with luminal subtype of the primary tumor compared to Her2+/TN breast cancer (p = 0.007). Multivariate Cox models showed that BmsI and TaqI are significantly associated with BC outcome. Patients with the major alleles showed more than 30% lower hazard of relapse (BsmI p = 0.02 and TaqI p = 0.03). Our study supports the evidence for a pivotal role of 25OHD metabolism in BC. GC SNPs may influence the hormone tumor responsiveness and VDR may affect tumor prognosis.
- Subjects
BREAST cancer prognosis; CELL receptors; VITAMIN D metabolism; SURVIVAL; SINGLE nucleotide polymorphisms; MULTIVARIATE analysis; CANCER relapse; ALLELES; CARRIER proteins; PROPORTIONAL hazards models; CELL physiology
- Publication
Nutrients, 2021, Vol 13, Issue 4, p1208
- ISSN
2072-6643
- Publication type
Article
- DOI
10.3390/nu13041208