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- Title
A Genome-Wide Association Study Identifies the Association between the 12q24 Locus and Black Tea Consumption in Japanese Populations.
- Authors
Furukawa, Kyohei; Igarashi, Maki; Jia, Huijuan; Nogawa, Shun; Kawafune, Kaoru; Hachiya, Tsuyoshi; Takahashi, Shoko; Saito, Kenji; Kato, Hisanori
- Abstract
Several genome-wide association studies (GWASs) have reported the association between genetic variants and the habitual consumption of foods and drinks; however, no association data are available regarding the consumption of black tea. The present study aimed to identify genetic variants associated with black tea consumption in 12,258 Japanese participants. Data on black tea consumption were collected by a self-administered questionnaire, and genotype data were obtained from a single nucleotide polymorphism array. In the discovery GWAS, two loci met suggestive significance (p < 1.0 × 10−6). Three genetic variants (rs2074356, rs144504271, and rs12231737) at 12q24 locus were also significantly associated with black tea consumption in the replication stage (p < 0.05) and during the meta-analysis (p < 5.0 × 10−8). The association of rs2074356 with black tea consumption was slightly attenuated by the additional adjustment for alcohol drinking frequency. In conclusion, genetic variants at the 12q24 locus were associated with black tea consumption in Japanese populations, and the association is at least partly mediated by alcohol drinking frequency.
- Subjects
JAPAN; THERAPEUTIC use of tea; COMPARATIVE studies; DRINKING (Physiology); DRINKING behavior; ALCOHOL drinking; FOOD habits; GENOMES; META-analysis; QUESTIONNAIRES; SINGLE nucleotide polymorphisms; GENOTYPES
- Publication
Nutrients, 2020, Vol 12, Issue 10, p3182
- ISSN
2072-6643
- Publication type
Article
- DOI
10.3390/nu12103182