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- Title
First Trimester Maternal Vitamin D Status and Risks of Preterm Birth and Small-For-Gestational Age.
- Authors
Monier, Isabelle; Baptiste, Amandine; Tsatsaris, Vassilis; Senat, Marie-Victoire; Jani, Jacques; Jouannic, Jean-Marie; Winer, Norbert; Elie, Caroline; Souberbielle, Jean-Claude; Zeitlin, Jennifer; Benachi, Alexandra
- Abstract
Maternal 25-hydroxyvitamin D (25-OHD) deficiency during pregnancy may increase the risk of preterm and small-for-gestational age (SGA) birth, but studies report conflicting results. We used a multicenter prospective cohort of 2813 pregnant women assessed for 25-OHD levels in the first trimester of pregnancy to investigate the association between maternal 25-OHD concentrations and risks of preterm birth (<37 weeks) and SGA (birthweight <10th percentile). Odds ratios were adjusted (aOR) for potential cofounders overall and among women with light and dark skin separately, based on the Fitzpatrick scale. 25-OHD concentrations were <20 ng/mL for 45.1% of the cohort. A total of 6.7% of women had a preterm birth. The aOR for preterm birth associated with the 1st quartile of 25-OHD concentrations compared to the 4th quartile was 1.53 (95% confidence interval (CI): 0.97–2.43). In stratified analyses, an association was observed for women with darker skin (aOR = 2.89 (95% CI: 1.02–8.18)), and no association with lighter skin. A total of 11.9% of births were SGA and there was no association overall or by skin color. Our results do not provide support for an association between maternal first trimester 25-OHD deficiency and risk of preterm or SGA birth overall; the association with preterm birth risk among women with darker skin requires further investigation.
- Subjects
BIRTH size; CONFIDENCE intervals; PREMATURE infants; LONGITUDINAL method; MEDICAL cooperation; FIRST trimester of pregnancy; PREGNANT women; RESEARCH; RISK assessment; SKIN; VITAMIN D; ODDS ratio; PREGNANCY
- Publication
Nutrients, 2019, Vol 11, Issue 12, p3042
- ISSN
2072-6643
- Publication type
Article
- DOI
10.3390/nu11123042