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- Title
Effect of PolyGlycopleX (PGX) Consumption on Blood Lipid Profiles in Healthy, Low CVD Risk Overweight Adults.
- Authors
Solah, Vicky A.; Kerr, Deborah A.; Irawati, Deasy; Hunt, Wendy; Meng, Xingqiong; Gahler, Roland J.; Fenton, Haelee K.; Johnson, Stuart K.; James, Anthony P.; Wood, Simon
- Abstract
Raised blood lipid levels are associated with a risk of a cardiovascular disease (CVD). Moderate reductions in several CVD factors such as total, low-density lipoprotein (LDL) cholesterol and non-high-density lipoprotein (non-HDL) cholesterol concentrations may be more effective in reducing overall risk than a major reduction in just one. A blind, randomised controlled trial was conducted with 120 healthy overweight (BMI 25–30) adults aged 25–70 years who were non-smokers, not diabetic and of low risk of cardiovascular disease, as assessed by the Framingham risk equation. Participants consumed 4.5 g PolyGlycopleX (PGX) as softgel capsules (PGXS) or 5 g PGX granules (PGXG) or 5 g rice flour (RF) with meals three times a day for 12 weeks. Total, LDL and non-HDL cholesterol were all significantly reduced (−6%, −5% and −3.5%, respectively) post the PGX granule treatment; however, PGX in softgel capsule form did not affect blood lipid profiles. Daily consumption of PGX granules in overweight low CVD risk adults produced lipid changes indicating a CVD preventative benefit.
- Subjects
CARDIOVASCULAR disease prevention; CARDIOVASCULAR diseases risk factors; DIETARY fiber; LIPIDS; LOW density lipoproteins; OBESITY; POLYSACCHARIDES; RANDOMIZED controlled trials; TREATMENT effectiveness; DESCRIPTIVE statistics
- Publication
Nutrients, 2019, Vol 11, Issue 4, p717
- ISSN
2072-6643
- Publication type
Article
- DOI
10.3390/nu11040717