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- Title
Comparison of <sup>68</sup>Ga-DOTA-Siglec-9 and <sup>18</sup>F-Fluorodeoxyribose-Siglec-9: Inflammation Imaging and Radiation Dosimetry.
- Authors
Virtanen, Helena; Silvola, Johanna M. U.; Autio, Anu; Xiang-Guo Li; Liljenbäck, Heidi; Hellberg, Sanna; Siitonen, Riikka; Ståhle, Mia; Käkelä, Meeri; Airaksinen, Anu J.; Helariutta, Kerttuli; Tolvanen, Tuula; Veres, Tibor Z.; Saraste, Antti; Knuuti, Juhani; Jalkanen, Sirpa; Roivainen, Anne
- Abstract
Sialic acid-binding immunoglobulin-like lectin 9 (Siglec-9) is a ligand of inflammation-inducible vascular adhesion protein-1 (VAP-1).We compared 68Ga-DOTA- and 18F-fluorodeoxyribose-(FDR-) labeled Siglec-9motif peptides for PET imaging of inflammation. Methods. Firstly, we examined 68Ga-DOTA-Siglec-9 and 18F-FDR-Siglec-9 in rats with skin/muscle inflammation. We then studied 18F-FDR-Siglec-9 for the detection of inflamed atherosclerotic plaques in mice and compared it with previous 68Ga-DOTA-Siglec-9 results. Lastly, we estimated human radiation dosimetry fromthe rat data. Results. In rats, 68Ga-DOTA-Siglec-9 (SUV, 0.88 ± 0.087) and 18F-FDR-Siglec-9 (SUV, 0.77 ± 0.22) showed comparable (P = 0.29) imaging of inflammation. In atherosclerotic mice, 18FFDR-Siglec-9 detected inflamed plaques with a target-to-background ratio (1.6 ± 0.078) similar to previously tested 68Ga-DOTASiglec-9 (P = 0.35).Human effective dose estimates for 68Ga-DOTA-Siglec-9 and 18F-FDR-Siglec-9were 0.024 and 0.022 mSv/MBq, respectively. Conclusion. Both tracers are suitable for PET imaging of inflammation. The easier production and lower cost of 68Ga-DOTA-Siglec-9 present advantages over 18F-FDR-Siglec-9, indicating it as a primary choice for clinical studies.
- Publication
Contrast Media & Molecular Imaging, 2017, Vol 2017, p1
- ISSN
1555-4309
- Publication type
Article
- DOI
10.1155/2017/7645070