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- Title
Prevalence and Patterns of Morphological Abnormalities in Patients With Childhood Cancer.
- Authors
Merks, Johannes H. M.; Özgen, Heval M.; Koster, Jan; Zwinderman, Aeilko H.; Caron, Huib N.; Hennekam, Raoul C. M.
- Abstract
This article presents the results of a study of children with cancer to assess the prevalence of genetic polymorphisms in order to identify tumor predisposition. There have been studies that show developmental genes which form the body during embryogenesis are also involved in the development of childhood cancers. 1073 children with childhood cancer underwent detailed clinical examination to detect abnormalities that are associated with cancer and this information was compared to a cohort study of children without cancer studied in the same way. The study found significantly higher genetic polymorphisms in the cancer patients. Major abnormalities were found in 26.8 percent of the cancer patients and minor anomalies were found in 65.1 percent.
- Subjects
CHILDHOOD cancer; CANCER genetics; GENETIC polymorphisms; EMBRYOLOGY; FETAL development; GENETIC disorders; MEDICAL genetics; HUMAN genetics; GENETICS of disease susceptibility
- Publication
JAMA: Journal of the American Medical Association, 2008, Vol 299, Issue 1, p61
- ISSN
0098-7484
- Publication type
Article
- DOI
10.1001/jama.2007.66