We found a match
Your institution may have rights to this item. Sign in to continue.
- Title
Effect of Breast Augmentation on the Accuracy of Mammography and Cancer Characteristics.
- Authors
Miglioretti, Diana L.; Rutter, Carolyn M.; Geller, Berta M.; Cutter, Gary; Barlow, William E.; Rosenberg, Robert; Weaver, Donald L.; Taplin, Stephen H.; Ballard-Barbash, Rachel; Carney, Patricia A.; Yankaskas, Bonnie C.; Kerlikowske, Karla
- Abstract
Context: Breast augmentation is not associated with an increased risk of breast cancer; however, implants may interfere with the detection of breast cancer thereby delaying cancer diagnosis in women with augmentation. Objective: To determine whether mammography accuracy and tumor characteristics are different for women with and without augmentation. Design, Setting, and Participants: A prospective cohort of 137 women with augmentation and 685 women without augmentation diagnosed with breast cancer between January 1, 1995, and October 15, 2002, matched (1:5) by age, race/ethnicity, previous mammography screening, and mammography registry, and 10 533 women with augmentation and 974 915 women without augmentation and without breast cancer among 7 mammography registries in Denver, Colo; Lebanon, NH; Albuquerque, NM; Chapel Hill, NC; San Francisco, Calif; Seattle, Wash; and Burlington, Vt. Main Outcome Measures: Comparison between women with and without augmentation of mammography performance measures and cancer characteristics, including invasive carcinoma or ductal carcinoma in situ, tumor stage, nodal status, size, grade, and estrogen-receptor status. Results: Among asymptomatic women, the sensitivity of screening mammography based on the final assessment was lower in women with breast augmentation vs women without (45.0% [95% confidence interval {CI}, 29.3%-61.5%] vs 66.8% [95% CI, 60.4%-72.8%]; P = .008), and specificity was slightly higher in women with augmentation (97.7% [95% CI, 97.4%-98.0%] vs 96.7% [95% CI, 96.6%-96.7%]; P<.001). Among symptomatic women, both sensitivity and specificity were lower for women with augmentation compared with women without but these differences were not significant. Tumors were of similar stage, size, estrogen-receptor status, and nodal status but tended to be lower grade (P = .052) for women with breast augmentation vs without. Conclusions: Breast augmentation decreases the sensitivity of screening mammography among asymptomatic women but does not increase the false-positive rate. Despite the lower accuracy of mammography in women with augmentation, the prognostic characteristics of tumors are not influenced by augmentation.
- Subjects
UNITED States; AUGMENTATION mammaplasty; MAMMOGRAMS; HEALTH outcome assessment; CANCER in women; BREAST cancer research; TUMOR classification; ESTROGEN receptors; CANCER risk factors
- Publication
JAMA: Journal of the American Medical Association, 2004, Vol 291, Issue 4, p442
- ISSN
0098-7484
- Publication type
Article
- DOI
10.1001/jama.291.4.442