We found a match
Your institution may have rights to this item. Sign in to continue.
- Title
Lack of cardiac manifestations among patients with previously treated Lyme disease.
- Authors
Sangha, Oliver; Phillips, Charlotte B.; Fleishmann, Kirsten E.; Wang, Thomas J.; Fossel, Anne H.; Lew, Robert; Liang, Matthew H.; Shadick, Nancy A.; Sangha, O; Phillips, C B; Fleischmann, K E; Wang, T J; Fossel, A H; Lew, R; Liang, M H; Shadick, N A
- Abstract
<bold>Background: </bold>Cardiac involvement is common in acute Lyme disease, and case reports suggest that cardiac abnormalities might also occur years after the primary infection.<bold>Objective: </bold>To determine the prevalence of cardiac abnormalities in persons with previously treated Lyme disease.<bold>Design: </bold>Population-based, retrospective cohort study with controls.<bold>Setting: </bold>Nantucket Island, Massachusetts.<bold>Participants: </bold>From among 3703 adult respondents to a total-population (n = 6046) mail survey, 336 (176 case-patients and 160 controls) were randomly selected for clinical evaluation.<bold>Measurements: </bold>Current cardiac symptoms and major or minor abnormal electrocardiographic features, including heart rate; rhythm; axis; PR, QRS, and QT intervals; QRS structure; atrioventricular blocks; and ST-segment and T-wave changes.<bold>Results: </bold>Persons with Lyme disease (case-patients, n = 176) (mean duration from disease onset to study evaluation, 5.2 years) and persons without evidence of previous Lyme disease (controls, n = 160) did not differ significantly in their patterns of current cardiac symptoms and electrocardiographic findings, including heart rate (P > 0.2), PR interval (P = 0.15), QRS interval (P > 0.2), QT interval (P > 0.2), axis (P > 0.2), presence of arrhythmias (P > 0.2), first-degree heart block (P = 0.12), bundle-branch block (P > 0.2), and ST-segment abnormalities (P > 0.2). In multivariate analyses that adjusted for age, sex, and previous heart disease, a history of previously treated Lyme disease was not associated with either major (odds ratio, 0.78; P > 0.2) or minor (odds ratio, 1.09; P > 0.2) electrocardiographic abnormalities.<bold>Conclusion: </bold>Persons with a history of previously treated Lyme disease do not have a higher prevalence of cardiac abnormalities than persons without a history of Lyme disease.
- Subjects
LYME disease; HEART diseases
- Publication
Annals of Internal Medicine, 1998, Vol 128, Issue 5, p346
- ISSN
0003-4819
- Publication type
journal article
- DOI
10.7326/0003-4819-128-5-199803010-00002