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- Title
Cytomegalovirus is frequently isolated in bronchoalveolar lavage fluid of bone marrow transplant recipients without pneumonia.
- Authors
Ruutu, Petri; Ruutu, Tapani; Volin, Liisa; Tukiainen, Pentti; Ukkonen, Pentti; Hovi, Tapani; Ruutu, P; Ruutu, T; Volin, L; Tukiainen, P; Ukkonen, P; Hovi, T
- Abstract
We prospectively studied the presence of cytomegalovirus in bronchoalveolar lavage through virus isolation in 21 bone marrow transplant recipients before and after transplantation. All 14 lavage specimens collected before bone marrow transplantation were negative for cytomegalovirus. During the period from 20 to 90 days after transplantation, 12 of 24 lavage specimens (50%) from 14 patients without lung problems were positive for cytomegalovirus. Cytomegalovirus was isolated from 4 of 10 lavage specimens (40%) in 7 patients with pneumonia during the same interval. We conclude that culture for cytomegalovirus in bronchoalveolar lavage fluid is not a reliable method for establishing the virus's causative role in pneumonia soon after bone marrow transplantation. Among 14 patients in whom bronchoalveolar lavage was done at an asymptomatic stage, 6 of 9 patients with cytomegalovirus and none of 5 without cytomegalovirus in the lavage fluid later developed pneumonia. All of the patients subsequently developing pneumonia also had acute graft-versus-host disease, suggesting an immunopathologic mechanism, possibly triggered by cytomegalovirus, for cytomegalovirus-associated pneumonia.
- Subjects
CYTOMEGALOVIRUS diseases; BRONCHOALVEOLAR lavage; BONE marrow transplantation; CYTOMEGALOVIRUS disease diagnosis; GRAFT versus host disease prevention; BODY fluids; COMPARATIVE studies; CYTOMEGALOVIRUSES; GRAFT versus host disease; LONGITUDINAL method; RESEARCH methodology; MEDICAL cooperation; RESEARCH; TIME; VIRAL pneumonia; EVALUATION research; DISEASE complications
- Publication
Annals of Internal Medicine, 1990, Vol 112, Issue 12, p913
- ISSN
0003-4819
- Publication type
journal article
- DOI
10.7326/0003-4819-112-12-913